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Both semaglutide and tirzepatide are well-known for their effects on weight loss and blood sugar control, but our study suggests they may also offer substantial benefits to patients with obesity and type 2 diabetes by reducing adverse heart failure outcomes. Despite promising results from existing randomized controlled trials of semaglutide and tirzepatide in those with obesity-related HFpEF, regulatory authorities and professional societies have not approved or endorsed the use of these drugs for HFpEF, due in part to the studies relatively small sample sizes and unknown generalizability

10.1016/j.metabol.2024.155813 52 PerreaultL.DaviesM.FriasJ

Timeline Expectations: What to Expect Month by Month Setting realistic expectations improves adherence and reduces premature discontinuation

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As the donut gets thicker (hypertrophy), the hole in the middle gets tighter